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KMID : 0370219870310020082
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Yakhak Hoeji
1987 Volume.31 No. 2 p.82 ~ p.91
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The Effect of 6-Hydroxydopamine on the Hypotensive Action and Contractile Force of Isolated Vas Deferens Smooth Muscle by Clonidine
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윤재순/Yun JS
장문희/Chang MH
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Abstract
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The effect of neurotoxic compound 6-hydroxydopamine (6-OHDA) on the change in blood pressure and contractile response of Vas deference by centrally acting agents has been studied in normal and DOCA-salt induced hypertensive rats. The treatment of neonatal rats with 6-OHDA (2 X 1OOmg, 250mg Kg-1 s.c) significantly inhibited the antihypertensive and relaxant effects of Vas deference of clonidine(100mcg Kg-1 iv.). The simultaneous administration of desipramine with clonidine into neonatal rats decreased the antihypertensive response of clonidine although treated did not affect the relaxative response of Vas deference. Furthermore, the antihypertensive and relaxant responses of clonidine were reduced by the neonatal rats with 6-OHDA regardless of the administration of desipramine. When neonatal rats were administered with 6-OHDA, the development of DOCA-salt hypertension was prevented. These results suggest that 6-OHDA, clonidine and desipramine had a significant effect on the development and the inhibition of central hypertension mediating the central adrenergic neuron due to their affinity to the central nervous system.
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